A national trade union center (or national center or central) is a federation or confederation of trade unions in a country. Nearly every country in the world has a national trade union center, and many have more than one. In some regions, such as the Nordic countries, different centers exist on a sectoral basis, for example, for blue collar workers and professionals.

Among the larger national centers in the world are the American Federation of Labor-Congress of Industrial Organizations and the Change to Win Federation in the USA; the Canadian Labour Congress; the Trades Union Congress (TUC) in Britain; the Irish Congress of Trade Unions; the Australian Council of Trade Unions (ACTU); the Congress of South African Trade Unions; the Dutch FNV; the Danish, Norwegian, and Swedish LO; the German DGB; the French CGT and CFDT; the Indian BMS, INTUC, AITUC and HMS; the Italian CISL, CGIL and UIL; the Spanish CCOO, CNT, CGT and USO; the Czech ČMKOS; the Japan Trade Union Confederation RENGO; the Argentinian CGT and CTA; the Brazilian CUT; the Armenian CTUA, and so on.

Many national trade union centers are now members of the International Trade Union Confederation, although some belong to the World Federation of Trade Unions.